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2022 New Stock Active Pharmaceutical Ingredients Articaine CAS 23964
Basic Info.
| Model NO. | 23964-58-1 |
| Logp | 2.63360 |
| Psa | 95.67000 |
| Exact Mass | 284.11900 |
| Vapour Pressure | 5.79e-08mmhg at 25°c |
| Water Solubility | 101.5mg/L(25 ºC) |
| Einecs | 607-295-0 |
| CAS | 23964-58-1 |
| CAS No. | 23964-58-1 |
| Boiling Point | 440.6ºC at 760 Mmhg |
| Density | 1.178 g/cm3 |
| Molecular Weight | 284.37500 |
| Appearance | Powder |
| Type | Pharmaceutical Intermediates |
| Quality | Refined |
| Colour | White |
| Formula | C13h20n2o3s |
| Transport Package | Packing Within 3 Working Days |
| Specification | 25kg/Cardboard barrel |
| Trademark | Wuhan Mulei |
| Origin | Hebei |
| HS Code | 2934990002 |
| Production Capacity | 500000kg |
Product Description
Articaine
Articaine structure | Common Name | Articaine | ||
|---|---|---|---|---|
| CAS Number | 23964-58-1 | Molecular Weight | 284.37500 | |
| Density | 1.178 g/cm3 | Boiling Point | 440.6ºC at 760 mmHg | |
| Molecular Formula | C13H20N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 220.3ºC | |
| Symbol | GHS07 | Signal Word | Warning | |
Use of Articaine Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3]. |
Product Description
| Product name | Articaine |
| CAS | 23964-58-1 |
| Appearance | white powder |
| Assay | 99% |
| Storage | Cool and Protect from light |
Articaine Descriptions:
Articaine
Product Name Articaine
CAS 23964-58-1
MF C13H20N2O3S
MW 284.37
EINECS 607-295-0
MOL File 23964-58-1.mol
Chemical Properties
Melting point 175-176 °C
Boiling point bp0.3 162-167°
Density 1.178±0.06 g/cm3(Predicted)
pka 13.46±0.70(Predicted)
CAS DataBase Reference 23964-58-1(CAS DataBase Reference)
Articaine [4-methyl-3-(2-propylaminopropionamido) thiophen-2-carboxylic acid methyl ester hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year 2000 because of its quick onset and short duration of action. The structure of articaine differs from those of all other amino amide-type local anesthetics in that it contains a thiophen ring instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by plasma cholinesterases because of the presence of an ester group and, therefore, has a much shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine). Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine, articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for dental procedures.
Usage And Synthesis
Articaine [4-methyl-3-(2-propylaminopropionamido) thiophenne-2-carboxylic acid methyl ester hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year 2000 because of its quick onset and short duration of action. The structure of articaine differs from those of all other amino amide-type local anesthetics in that it contains a thiophenne ring instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by plasma cholinesterases because of the presence of an ester group and, therefore, has a much shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine). Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine, articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for dental procedures.
Articaine Function
Bupivacaine hydrochloride (Marcaine, Sensorcaine) has particularly long action, and some nerve blocks last more than 24 hours; this is often an advantage for postoperative analgesia. Its use for epidural anesthesia in obstetrics has attracted interest because it can relieve the pain of labor at concentrations as low as 0.125% while permitting some motor activity of abdominal muscles to aid in expelling the fetus. The lower concentration minimizes the possibility of cardiac toxicity. Fetal drug concentrations remain low, and drug-induced neurobehavioral changes are not observed in the newborn. Bupivacaine also is approved for spinal anesthesia and is approximately four times more potent and more toxic than mepivacaine and lidocaine. It can be used with or without epinephrin.
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior tosurgical procedures such as cataract extraction and pterygium excision, usually as an adjunct tolocally injected anesthetics. Ophthalmic solutions used for intraocular procedures should bepreservative-free.Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.
Articaine uses:
Uses Articaine is an amide that also contains an ester linkage, which is hydrolysed rapidly so that the duration of action is short. It is available as a 4% solution with adrenalin for infiltration anaesthesia in dentistry.Uses Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand , food surgery and in dentistry.
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Detailed Photos
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Storage:
1. Stored in a clean, cool and dry area; keep away from strong, direct light.
2. Shelf Life is 2 years when properly stored.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. In stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement
Shipping:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
Hot sell products:
| CHEMICAL NAME | CAS No. | STATE | PRICE | FREE SAMPLE |
| Benzocaine | 94-09-7 | IN STOCK | Negotiable | Available |
| Benzocaine HCI | 23239-88-5 | IN STOCK | Negotiable | Available |
| Lidocaine | 137-58-6 | IN STOCK | Negotiable | Available |
| Lidocaine hydrochloride | 73-78-9 | IN STOCK | Negotiable | Available |
| Tetracaine | 94-24-6 | IN STOCK | Negotiable | Available |
| Boric acid | 11113-50-1 | IN STOCK | Negotiable | Available |
| Levamisole (hydrochloride) | 16595-80-5 | IN STOCK | Negotiable | Available |
| Procaine (HCI) | 51-05-8 | IN STOCK | Negotiable | Available |
| Procaine | 59-46-1 | IN STOCK | Negotiable | Available |
Payment term:
We accept various payment terms, the main methods are : T/T, L/C, Western Union, credit card, Bitcoin, USDT etc.
Shipping term:
Our Advantages
WHY CHOOSE US
MU LEI (Wuhan) is committed to helping clients reach their goals, to providing high quality products and efficient shipments.
Our strong sense of responsibility with client projects means that we are constantly striving to provide solutions, even for issues they aren't yet aware of.
This sense of responsibility also means we value and promote seamless interaction with clients, and ensure the best value is obtained from their research budget.
Our staff bring professional knowledge to clients, as well as efficient responding to the clients, have built long-term cooperated relationships.
FAQ
In this page, we will continue to update frequently asked questions and answers about the crystaline, Benzocaine powder, Lidocaine hcl powder, Procaine hcl crystal, fluffy Lidocaine, tetracaine chemical, crystaline tetramisole hydrochloride, cas and so on, Stay tuned....QWhat's your advantage?
AThe series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict quality management system and cost control system, ensure the product stability and competitive price.
QHow to deal with quality complaints or the goods get loss?
AFirstly, every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA (or depends on customers' request).
If it is our product quality issue or due to the force majeures, we will send you another shipment for free.
QIs there any discount?
AThe price is negotiable. The more bigger quantity you order, the more competitive price you would get.
QHow do you manage the delivery?
AGoods will be shipped within 24 hours (Chinese public holiday are excluded), usually shipping by DHL, Fedex, EMS, TNT, HKETK. We will ship with the special safe channel to ensure you getting goods on time.QHow to place an order?
AInquiry + payment + shipping.Firstly, please send inquiry infor to us, including quantity, your target price, shipping method, packing request, destination etc. We will reply you the quotation and lead time within 1-8 hours (different time zone).
Second, pay for the order, we accept various payment terms, the main methods are: T/T, L/C, Western Union, credit card, BitCoin, USDT, Money Gram.After received the payment, we will ship out products immediately and share tracking number with you.And for sure, we keep tracking the shippment, and we provide after-service.
QCan I get some samples?
AWarmly welcome, we can provide samples for free, but the shipping cost will be covered by customers.